The effect of Kardeh (Biarum Bovei) Hydro-alcoholic extract on pain threshold in STZ induced diabetic rats

Background & Aim: Diabetes mellitus in long-term through various means such as augmented oxidative stress is associated with disturbances such as pain and cognition in humans and laboratory animals. According to the evidence of anti-diabetic extract of Biarum Bovei (BB), Effect of oral administration of this extract was evaluated on blood glucose level and pain threshold in diabetic rats. Experimental: Animals were divided into; Control (intact), diabetic (STZ 70 mg /kg) and diabetic group that received Biarum Bovei Extract (BBE) (50, 100, 200, 400, 800 mg/kg) for two weeks by gavage. Blood glucose was measured from tail blood, then performed tail filick test to measure pain threshold. The results were analyzed statistically through SPSS, One way ANOVA and Tukey's test. Diabetes led to a decrease in blood glucose (p < 0.001) and pain threshold (p <0.001) prescribed doses (100, 200 mg/kg) BBE resulted a decrease in blood glucose (p  Results & Discussion: The findings of this study showed that Hydro-alcoholic extract of kadeh (BB) possibly with high-antioxidant property is able to reduce blood glucose and diabetes complications such as pain in animals. Recommended applications/industries: Considering the low side effects of herbal medicines, especially antioxidants including Kardeh can be used to reduce the complications of diabetes with drug therapy.